Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials?
H. Bart van der Worp, Malcolm R.Macleod, Rainer Kollmar

Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis
H. Bart van der Worp, Emily S. Sena, Geoffrey A. Donnan, David W.Howells and Malcolm R.Macleod

Therapeutic Hypothermia for Acute Ischemic Stroke: What Do Laboratory Studies Teach Us?
Derk W. Krieger, MD; Midori A. Yenari, MD

Therapeutic hypothermia for stroke: do new outfits change an old friend?
Rishi Gupta, Tudor G Jovin and Derk W Krieger

Cooling for Acute Ischemic Brain Damage (COOL AID): A feasibility trial of endovascular cooling
M.A. De Georgia, MD; D.W. Krieger, MD; A. Abou-Chebl, MD; T.G. Devlin, MD, PhD; M. Jauss, MD; S.M. Davis, MD, FRACP; W.J. Koroshetz, MD; G. Rordorf, MD; and S. Warach, MD, PhD


Lancet Stroke Symposium
Geoff Donnan, Marc Fisher, Malcolm Macleod, Stephen Davis

Acute Ischaemic Stroke (NEJM)
Bart van der Worp and Jan van Gijn

Hypothermia Call for Action

In 2010 a consensus meeting hosted by EuroHYP agreed the Hypothermia: Call for Action, later published in the International Journal of Stroke

Rationale for trial design

In this JCBFM Review Article> the EuroHYP investigators discuss the various considerations which have led to the design of the EuroHYP trial protocol

Supporting Experimental Data

In one of the most highly cited systematic reviews of animal studies van der Worp and colleagues show that animal data supporting hypothermia is more convincing than for any other intervention