COoling in Acute STroke II (COAST II)
A randomised, monocenter study on endovascular cooling to 35°C following the induction of hypothermia by ice cold saline. Patients included into the study are standard thrombolysed patients (time window 3 hours)
Hypothermia for Acute Ischaemic Stroke Trial - Edinburgh (HAIST-E)
A randomised pilot study of surface cooling to 35ºC or 33ºC degrees for 12 or 24 hours, with MR spectroscopy measurement of brain temperature.
Supported by Chest Heart and Stroke Scotland
Hypothermia for Acute Ischaemic Stroke Trial - Utrecht (HAIST-U)
A randomised pilot study of surface cooling to 35ºC or 33ºC degrees for 12 or 24 hours
Malmö Acute Stroke Cooling Trial (MASCOT)
A randomised pilot study of surface cooling to 33ºC for 24 hours in ventilated patients who have failed to improve with conventional therapy
Mild Hypothermia in Acute Ischemic Stroke: Safety and Feasibility Study (MHAIS)
A randomised pilot study of surface cooling to 35C for 12 hours in patients who have failed to improve within 2 hrs of tPA treatment.
Hypothermia in Acute Ischemic Stroke: Surface versus Endovascular Cooling afety and Feasibility Study (HAiS-SE)
A prospective, controlled,randomised trial comparing the feasibility, tolerability and safety of surface cooling (CSZ Blanketrol III) versus endovascular cooling (Zoll Thermogard XP) versus standard stroke treatment (ESO Guidelines).
For more details about the hypothermia studies conducted at Heidleberg University Hospital please see http://www.klinikum.uni-heidelberg.de/HYPO
Cooling in Intracerebral Hemorrhage (CINCH)
A prospective, multicentre German-Austrian randomised controlled trial of 50 patients with large primary ICH within 6 to 18 hours of onset treated with therapeutic hypothermia to 35ºC.
In 2010 a consensus meeting hosted by EuroHYP agreed the Hypothermia: Call for Action, later published in the International Journal of Stroke
In this JCBFM Review Article> the EuroHYP investigators discuss the various considerations which have led to the design of the EuroHYP trial protocol
In one of the most highly cited systematic reviews of animal studies van der Worp and colleagues show that animal data supporting hypothermia is more convincing than for any other intervention